Season 2
The season continued to focus on the surgical residency of five young interns as they try to balance to the challenges of their competitive careers, with the difficulties that determine their personal lives. It was set in the fictional Seattle Grace Hospital, located in the city of Seattle, Washington. Whereas the first season put the emphasis mainly on the unexpected impact the surgical field has on the main characters, the second one provides a detailed perspective on the personal background of each character, focusing on the consequences that their decisions have on their careers. Throughout the season, new story lines were introduced, including the love triangle between Meredith Grey, Derek Shepherd, and Addison Montgomery, the main arc of the season. Also heavily developed was the story line involving Izzie Stevens' relationship with patient Denny Duquette, which resulted in critical acclaim and positive fan response.
Episodes
1 Raindrops Keep Falling on My Head Sep 25, 2005 
2 Enough Is Enough Oct 2, 2005 
3 Make Me Lose Control Oct 9, 2005 
4 Deny, Deny, Deny Oct 16, 2005 
5 Bring the Pain Oct 23, 2005 
6 Into You Like a Train Oct 30, 2005 
7 Something to Talk About Nov 6, 2005 
8 Let It Be Nov 13, 2005 
9 Thanks for the Memories Nov 20, 2005 
10 Much Too Much Nov 27, 2005 
11 Owner of a Lonely Heart Dec 4, 2005 
12 Grandma Got Run Over By a Reindeer Dec 11, 2005 
13 Begin the Begin Jan 15, 2006 
14 Tell Me Sweet Little Lies Jan 22, 2006 
15 Break on Through Jan 29, 2006 
16 It's the End of the World Feb 5, 2006 
17 As We Know It Feb 12, 2006 
18 Yesterday Feb 19, 2006 
19 What Have I Done to Deserve This? Feb 26, 2006 
20 Band-Aid Covers the Bullet Hole Mar 12, 2006 
21 Superstition Mar 19, 2006 
22 The Name of the Game Apr 2, 2006 
23 Blues for Sister Someone Apr 30, 2006 
24 Damage Case May 7, 2006 
25 17 Seconds May 14, 2006 
26 Deterioration of the Fight or Flight Response May 15, 2006 
27 Losing My Religion May 15, 2006