Season 21
Episodes
1 Johnny Knoxville; Olivia Cooke; BLACKPINK Sep 19, 2022 
2 Kathy Griffin; Chad Kroeger and JT Parr; Madison Cunningham Sep 20, 2022 
3 John Boyega; Tyler James Williams; Weezer Sep 21, 2022 
4 Allison Janney; Chris Estrada; Frankie Quiñones; Yung Gravy Sep 22, 2022 
5 Amy Schumer, Charlamagne Tha God, Run the Jewels Sep 26, 2022 
6 David Letterman, Tracy Morgan Sep 27, 2022 
7 Mila Kunis, Ramy Youssef, Future Sep 28, 2022 
8 Ben Stiller, Desus Nice, Yeah Yeah Yeahs Sep 29, 2022 
9 Jason Bateman, Action Bronson Sep 30, 2022 
10 Charlie Hunnam, Iliza Shlesinger, NAV, Don Toliver Oct 3, 2022 
11 Norman Reedus, Danielle Deadwyler, Miranda Lambert Oct 4, 2022 
12 Keanu Reeves, Judd Apatow, Phoenix Oct 5, 2022 
13 David Spade, FLO, Mookie Betts Oct 6, 2022 
14 Magic Johnson, Fortune Feimster, Wet Leg Oct 10, 2022 
15 Jamie Lee Curtis, Lucas Bravo, Midland, Jon Pardi Oct 11, 2022 
16 Jessica Chastain, Maren Morris Oct 12, 2022 
17 George Clooney, Julia Roberts, Omar Apollo Oct 13, 2022 
18 Josh Gad, Pamela Adlon, Ariel Elias Oct 24, 2022 
19 Charlize Theron, Lewis Hamilton, Armani White Oct 25, 2022 
20 Lupita Nyong'o, Danai Gurira, Letitia Wright, Duran Duran Oct 26, 2022 
21 Quentin Tarantino, Tenoch Huerta, Edgar Winter Oct 27, 2022 
22 Gwyneth Paltrow, Patton Oswalt Oct 31, 2022 
23 Mindy Kaling, Frank Grillo, Goose Nov 1, 2022 
24 Nick Kroll, Yvonne Strahovski, Viagra Boys Nov 2, 2022 
25 Rob McElhenney, Emayatzy Corinealdi Nov 3, 2022 
26 Dana Carvey, Jonathan Majors Nov 7, 2022 
27 Bill Maher, George Conway Nov 8, 2022 
28 Jason Momoa, Luke Grimes Nov 9, 2022 
29 Brian Tyree Henry, Lizzy Caplan Nov 10, 2022 
30 Chris Hemsworth, Meghann Fahy Nov 14, 2022 
31 Amy Adams, Maya Rudolph, Jenna Ortega Nov 15, 2022 
32 Kumail Nanjiani, Pink Nov 16, 2022 
33 Patrick Dempsey, Nicholas Hoult Nov 17, 2022 
34 Carey Mulligan, Josh Groban Nov 21, 2022 
35 Kristen Bell, David Shrigley Nov 22, 2022 
36 Kathryn Hahn, Dominic West Nov 28, 2022 
37 Billy Crystal, Kate Berlant Nov 29, 2022 
38 David Harbour, Lisa Ann Walter Nov 30, 2022 
39 Don Cheadle, Zoey Deutch Dec 1, 2022 
40 George Lopez, Haley Lu Richardson Dec 5, 2022 
41 Janelle Monáe, Sadie Sink, Rita Wilson Dec 6, 2022 
42 Will Ferrell, Colson "Machine Gun Kelly" Baker Dec 7, 2022 
43 Jean Smart, Wes Bentley Dec 8, 2022 
44 Michelle Obama, Marc Maron Dec 12, 2022 
45 Sigourney Weaver, Jovan Adepo Dec 13, 2022 
46 Margot Robbie, Jeremy Allen White Dec 14, 2022 
47 Brendan Fraser, Diego Calva Dec 15, 2022 
48 Seth Rogen, Diego Calva Jan 3, 2023 
49 Anna Kendrick, Jermaine Fowler, Sabrina Carpenter Jan 4, 2023 
50 Laura Dern, Jeremy Allen White Jan 5, 2023 
51 Joel McHale, Ali Wentworth Jan 6, 2023 
52 Austin Butler, Bella Ramsey, Iggy Pop, Peyton Manning, Eli Manning Jan 9, 2023 
53 Octavia Spencer, Ramon Rodríguez, Renee Rapp Jan 10, 2023 
54 Bryan Cranston Jan 11, 2023 
55 Viola Davis, Judd Hirsch Jan 12, 2023 
56 Danny DeVito, Lucy DeVito Jan 16, 2023 
57 Rob Lowe, Storm Reid, Seal Jan 17, 2023 
58 Jennifer Lopez, Chris Perfetti, Fall Out Boy Jan 18, 2023 
59 Lily Tomlin, Jane Fonda, Rita Moreno, Sally Field, Jacob Latimore Jan 19, 2023 
60 David Duchovny, Zach Shallcross Jan 23, 2023 
61 Julia Louis-Dreyfus, Rose Byrne, Bobby Cannavale Jan 24, 2023 
62 D'Arcy Carden, Hailey Whitters Jan 25, 2023 
63 George Clooney, Snoop Dogg, Coldplay Jan 26, 2023 
64 Salma Hayek Pinault, Billy Crudup, Justine Skye Jan 30, 2023 
65 Pamela Anderson, Mike Lindell, Fall Out Boy Jan 31, 2023 
66 Nick Offerman, Kerry Condon, Sofia Carson, Diane Warren Feb 1, 2023 
67 Reese Witherspoon, Wesley Kimmel, "Science Bob" Pflugfelder Feb 2, 2023 
68 Cate Blanchett, Patrick Mahomes, Dave Franco Feb 13, 2023 
69 Milo Ventimiglia, Charles Barkley, Paramore Feb 14, 2023 
70 Orlando Bloom, Lauren Ash, Jordan Davis Feb 15, 2023 
71 Katy Perry, Lionel Richie, Mike Epps, Beck Feb 16, 2023 
72 Wanda Sykes, RZA, Bailey Zimmerman Feb 21, 2023 
73 Keri Russell, Ms. Pat, Logic Feb 22, 2023 
74 Anthony Mackie, Chris Distefano, Gracie Abrams Feb 23, 2023 
75 Tom Cruise, Camila Morrone Feb 24, 2023 
76 Michael B. Jordan, Blake Shelton Feb 27, 2023 
77 Courteney Cox, Ike Barinholtz Feb 28, 2023 
78 Jon Favreau, Nicole Byer, Tove Lo Mar 1, 2023 
79 Paul Mescal, Kali Uchis Mar 2, 2023 
80 Owen Wilson, Guillermo del Toro Mar 13, 2023 
81 Seth Rogen, Rachel Zegler Mar 14, 2023 
82 David Letterman, Dominique Fishback Mar 15, 2023 
83 Andy Samberg, Lukas Gage, RAYE Mar 16, 2023 
84 Jennifer Hudson, Donnie Yen, Larkin Poe Mar 20, 2023 
85 Julie Bowen, Jamie Demetriou, Depeche Mode Mar 21, 2023 
86 Molly Shannon, Giancarlo Esposito, Nickel Creek Mar 22, 2023 
87 Jeff Goldblum, Teyana Taylor Mar 23, 2023 
88 Chris Pine, Dave Burd, The War and Treaty Mar 27, 2023 
89 Ben Affleck, Nicholas Braun, Chlöe Mar 28, 2023 
90 Jason Bateman, Ali Wong, Stray Kids Mar 29, 2023 
91 Viola Davis, Julius Tennon, Brett Goldstein, Daniel Caesar Mar 30, 2023 
92 Jeremy Renner Apr 10, 2023 
93 Carol Burnett, Wendi McLendon-Covey Apr 11, 2023 
94 Quinta Brunson Apr 12, 2023 
95 Bill Hader, Jane Goodall Apr 13, 2023 
96 Freddie Highmore, Amanda Peet, Dinner Party Apr 17, 2023 
97 Luke Bryan, Jeff Hiller, GloRilla Apr 18, 2023 
98 Patrick Stewart, Bridget Everett, Gorillaz featuring Beck Apr 19, 2023 
99 Jake Gyllenhaal, Whitney Cummings, boygenius Apr 20, 2023 
100 James Corden, Richard Madden, They Might Be Giants Apr 24, 2023 
101 John Mulaney, India Amarteifio, Cannons Apr 25, 2023 
102 Pierce Brosnan, Abby Ryder Fortson, New West Apr 26, 2023 
103 Chris Pratt, Lukas & Micah Nelson Apr 27, 2023 
104 Charlie Day, Padma Lakshmi, Bebe Rexha May 1, 2023