Season 4
After engineering a daring escape from the hellish, Panamanian prison Sona, brothers Michael Scofield and Lincoln Burrows are determined to seek justice against The Company, the shadowy group responsible for destroying their lives and killing the woman Michael loves, Dr. Sara Tancredi. Michael’s quest for vengeance leads him to Los Angeles, where his world is turned upside down when Company operative Gretchen/Susan B. Anthony informs him that Sara is still alive. Realizing the only way they will truly be free, Michael and Lincoln avow to find Sara and take down The Company. With the help of Homeland Security agent Don Self, they assemble a group of allies and familiar faces to accomplish their task: Mahone, Sucre, Bellick and computer expert Roland Glenn. Unfortunately for the brothers, they must also evade company assassin Wyatt and find an on-the-loose T-Bag. Michael and Lincoln soon discover the only thing harder than breaking out will be breaking in.
Episodes
1 Scylla Sep 1, 2008 
2 Breaking & Entering Sep 1, 2008 
3 Shut Down Sep 8, 2008 
4 Eagles and Angels Sep 15, 2008 
5 Safe and Sound Sep 22, 2008 
6 Blow Out Sep 29, 2008 
7 Five the Hard Way Oct 6, 2008 
8 The Price Oct 20, 2008 
9 Greatness Achieved Nov 3, 2008 
10 The Legend Nov 10, 2008 
11 Quiet Riot Nov 17, 2008 
12 Selfless Nov 24, 2008 
13 Deal Or No Deal Dec 1, 2008 
14 Just Business Dec 8, 2008 
15 Going Under Dec 15, 2008 
16 The Sunshine State Dec 22, 2008 
17 The Mother Lode Apr 17, 2009 
18 VS. Apr 24, 2009 
19 S.O.B. May 1, 2009 
20 Cowboys and Indians May 8, 2009 
21 Rate of Exchange May 15, 2009 
22 Killing Your Number May 15, 2009