Season 6
The prize: ending the Apocalypse. The price: Sam's life. Season 5's horrific finale left Dean alone, as Sam descended into Hell. Now a different man, Dean vows to stop hunting and devote himself to building a family with Lisa and her son Ben. Then, mysteriously, Sam reappears, drawing Dean back into the old life. But Sam's a different man too. He's returned without his soul. How the Winchesters confront this greatest challenge yet to their powerful bond is the troubled heart - and soul - of the profound and thrilling 22-Episode Season 6. As the brothers struggle to reunite, they must also battle deadly supernatural forces. Demons. Angels. Vampires. Shapeshifters. And a terrifying new foe called the Mother of All.
Episodes
1 Exile on Main St. Sep 24, 2010 
2 Two and a Half Men Oct 1, 2010 
3 The Third Man Oct 8, 2010 
4 Weekend at Bobby's Oct 15, 2010 
5 Live Free or Twihard Oct 22, 2010 
6 You Can't Handle the Truth Oct 29, 2010 
7 Family Matters Nov 5, 2010 
8 All Dogs Go to Heaven Nov 12, 2010 
9 Clap Your Hands If You Believe... Nov 19, 2010 
10 Caged Heat Dec 3, 2010 
11 Appointment in Samarra Dec 10, 2010 
12 Like a Virgin Feb 4, 2011 
13 Unforgiven Feb 11, 2011 
14 Mannequin 3: The Reckoning Feb 18, 2011 
15 The French Mistake Feb 25, 2011 
16 ...And Then There Were None Mar 4, 2011 
17 My Heart Will Go On Apr 15, 2011 
18 Frontierland Apr 22, 2011 
19 Mommy Dearest Apr 29, 2011 
20 The Man Who Would Be King May 6, 2011 
21 Let It Bleed May 20, 2011 
22 The Man Who Knew Too Much May 20, 2011